Itgam^tm1Myd
Targeted Allele Detail

Summary

• Symbol: Itgam^tm1Myd
• Name: integrin alpha M; targeted mutation 1, Tanya N Mayadas
• MGI ID: MGI:1931533
• Synonyms: Cd11b^-, CD11b/CD18 deficiency, CD11b KO, CR3-, Itgam^tm1Tmn, Mac-1^-
• Gene: Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
• Alliance: Itgam^tm1Myd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38052
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the exon encoding the translational initiation codon and 15 amino acids of the signal peptide with a neomycin cassette. (J:38052)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itgam Mutation: 48 strains or lines available

References

• Original: J:38052 Coxon A, et al., A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec;5(6):653-66
• All: 164 reference(s)