Jag1^Slalom
Chemically induced Allele Detail

Summary

• Symbol: Jag1^Slalom
• Name: jagged 1; slalom
• MGI ID: MGI:1931798
• Synonyms: Gena 158, Gena158, slalom, Slm
• Gene: Jag1 Location: Chr2:136923371-136958440 bp, - strand
• Alliance: Jag1^Slalom page

Mutation origin

• Strain of Origin: BALB/cAnNCrl
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A C to T missense mutation causes a proline to serine change at conserved codon 269 in the second epidermal growth factor (EGF)-like repeat. (J:63716, J:67728)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Jag1 Mutation: 78 strains or lines available

Notes

This mutation was induced by ENU treatment of a BALB/cAnNCrl male mouse that was then mated with C3H/HeNCrl females. Mapping of the dominant mutation was achieved using IVF-generated backcross progeny of the founder male x C3H females. (J:63816, J:67728)

References

• Original: J:67728 Tsai H, et al., The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet. 2001 Mar 1;10(5):507-12
• All: 4 reference(s)