Crkl^tm1Imo
Targeted Allele Detail

Summary

• Symbol: Crkl^tm1Imo
• Name: v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Akira Imamoto
• MGI ID: MGI:1931805
• Synonyms: Crkol -
• Gene: Crkl Location: Chr16:17269851-17305298 bp, + strand Genetic Position: Chr16, 10.82 cM
• Alliance: Crkl^tm1Imo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67826
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP flanked neo cassette was inserted in the first coding exon. Western blot analysis confirmed that no protein was expressed in homozygous mutant embryos. (J:67826)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crkl Mutation: 17 strains or lines available

References

• Original: J:67826 Guris DL, et al., Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. Nat Genet. 2001 Mar;27(3):293-8
• All: 7 reference(s)