Atp6v0c^tm1Hka
Targeted Allele Detail

Summary

• Symbol: Atp6v0c^tm1Hka
• Name: ATPase, H+ transporting, lysosomal V0 subunit C; targeted mutation 1, Hiroshi Kanazawa
• MGI ID: MGI:1931846
• Synonyms: Atp6l^tm1Hka, PL16-
• Gene: Atp6v0c Location: Chr17:24382839-24388652 bp, - strand Genetic Position: Chr17, 12.29 cM
• Alliance: Atp6v0c^tm1Hka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58416
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first translation initiation site in exon 1. The mRNA levels in tissues of heterozygous mutant animals are estimated to be about one half of wild-type levels. (J:58416)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp6v0c Mutation: 13 strains or lines available

References

• Original: J:58416 Inoue H, et al., Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H(+)-ATPase leads to early embryonic lethality. Biochim Biophys Acta. 1999 Nov 10;1413(3):130-8
• All: 2 reference(s)