Atp6v0ctm1Hka
Targeted Allele Detail
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Symbol: |
Atp6v0ctm1Hka |
Name: |
ATPase, H+ transporting, lysosomal V0 subunit C; targeted mutation 1, Hiroshi Kanazawa |
MGI ID: |
MGI:1931846 |
Synonyms: |
Atp6ltm1Hka, PL16- |
Gene: |
Atp6v0c Location: Chr17:24382839-24388652 bp, - strand Genetic Position: Chr17, 12.29 cM
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Alliance: |
Atp6v0ctm1Hka page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced the first translation initiation site in exon 1. The mRNA levels in tissues of heterozygous mutant animals are estimated to be about one half of wild-type levels.
(J:58416)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S1/Sv * C57BL/6 | |
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Phenotypes: |
Affected Systems |
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embryo
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failure of zygotic cell division
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abnormal embryonic tissue morphology
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abnormal inner cell mass morphology
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mortality/aging
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embryonic lethality before implantation, complete penetrance
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Atp6v0c Mutation: |
13 strains or lines available
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Original: |
J:58416 Inoue H, et al., Targeted disruption of the gene encoding the proteolipid subunit of mouse vacuolar H(+)-ATPase leads to early embryonic lethality. Biochim Biophys Acta. 1999 Nov 10;1413(3):130-8 |
All: |
2 reference(s) |
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