Hoxa1^tm2Ipc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm2Ipc
• Name: homeobox A1; targeted mutation 2, Pierre Chambon
• MGI ID: MGI:1931847
• Synonyms: Hoxa1^3'RARE, Hoxa1^{deltaRARE-(L)}
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm2Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38388
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 18 bps of the 3'RARE were replaced by a Sal1 restriction enzyme site. A lox-P flanked neomycin cassette was inserted into the Sal1 site and was later removed via Cre-mediated recombination in the final allele. (J:38388)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

53 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 14 strains or lines available

References

• Original: J:38388 Dupe V, et al., In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE). Development. 1997 Jan;124(2):399-410
• All: 3 reference(s)