Lrp2^tm1Her
Targeted Allele Detail

Summary

• Symbol: Lrp2^tm1Her
• Name: low density lipoprotein receptor-related protein 2; targeted mutation 1, Joachim Herz
• MGI ID: MGI:1931859
• Synonyms: megalin-, Meg KO
• Gene: Lrp2 Location: Chr2:69254679-69416373 bp, - strand Genetic Position: Chr2, 40.74 cM
• Alliance: Lrp2^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34835
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 1.5kb of sequence including sequences that encode the transmembrane region of the protein. Immunoblot analysis of kidney membranes did not detect the protein in homozygous mutant newborn mice. Immunohistochemical studies of 9.5 day homozygous mutant embryos did not detect the protein on the apical surface of the neuroepithelium. (J:34835)

Disease models

Expression

In Mice Carrying this Mutation:	28 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp2 Mutation: 261 strains or lines available

References

• Original: J:34835 Willnow TE, et al., Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8460-4
• All: 32 reference(s)