Ncoa3^tm1Jxu
Targeted Allele Detail

Summary

• Symbol: Ncoa3^tm1Jxu
• Name: nuclear receptor coactivator 3; targeted mutation 1, Jianming Xu
• MGI ID: MGI:1931860
• Synonyms: AIB1^-, SRC-3-
• Gene: Ncoa3 Location: Chr2:165834557-165915162 bp, + strand Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
• Alliance: Ncoa3^tm1Jxu page

Alveolar formation is reduced in the Ncoa3^tm1Jxu/Ncoa3^tm1Jxu mammary gland.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62724
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A TGK-neomycin resistance cassette replaced sequences spanning exon 2 through exon 13. The cassette introduced a lacZ sequence in frame with the endogenous promoter. The authors predict that the targeted allele would not produce a functional protein, but would produce a beta-galactosidase fusion protein controlled by the endogenous promoter. Western analysis did not detect wild-type protein in lactating mammary glands of homozygous mutant mice. (J:62724)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa3 Mutation: 233 strains or lines available

References

• Original: J:62724 Xu J, et al., The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6379-84
• All: 37 reference(s)