Ncoa3^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Ncoa3^tm1Rsd
• Name: nuclear receptor coactivator 3; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:1931861
• Synonyms: p/CIP-
• Gene: Ncoa3 Location: Chr2:165834557-165915162 bp, + strand Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
• Alliance: Ncoa3^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66454
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequences encoding the CREB-binding protein (CBP) binding domain and much of the nuclear receptor interaction domain. Immunoblot analysis of kidney extract did not detect NCOA3 in homozygous mutant animals. (J:66454)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa3 Mutation: 233 strains or lines available

References

• Original: J:66454 Wang Z, et al., Regulation of somatic growth by the p160 coactivator p/CIP. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13549-54
• All: 3 reference(s)