Slc1a3^tm1Kta
Targeted Allele Detail

Summary

• Symbol: Slc1a3^tm1Kta
• Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3; targeted mutation 1, Kohichi Tanaka
• MGI ID: MGI:1931872
• Synonyms: GLAST-, GLAST KO
• Gene: Slc1a3 Location: Chr15:8663608-8740248 bp, - strand Genetic Position: Chr15, 3.82 cM, cytoband A2
• Alliance: Slc1a3^tm1Kta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46746
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced sequences in exon 6 that code for the fourth transmembrane segment of the protein. Cerebellar transcript was not detected in homozygous mutant animals. Immunoblot analysis of cerebellar membranes did not detect protein in homozygous mutant mice. (J:46746)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc1a3 Mutation: 70 strains or lines available

References

• Original: J:46746 Watase K, et al., Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci. 1998 Mar;10(3):976-88
• All: 40 reference(s)