Smarcb1^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Smarcb1^tm1Sho
• Name: SWI/SNF related BAF chromatin remodeling complex subunit B1; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:1931875
• Synonyms: Snf5-
• Gene: Smarcb1 Location: Chr10:75732603-75757448 bp, - strand Genetic Position: Chr10, 38.61 cM
• Alliance: Smarcb1^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66417
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exon 1 of the Smarcb1 gene, including the initiation site. (J:66417)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smarcb1^tm1Sho

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smarcb1 Mutation: 22 strains or lines available

References

• Original: J:66417 Roberts CW, et al., Haploinsufficiency of snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13796-800
• All: 7 reference(s)