Xpc^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Xpc^tm1Brd
• Name: xeroderma pigmentosum, complementation group C; targeted mutation 1, Allan Bradley
• MGI ID: MGI:1931883
• Synonyms: XPC-, xpc^m1
• Gene: Xpc Location: Chr6:91466287-91492870 bp, - strand Genetic Position: Chr6, 40.55 cM, cytoband D
• Alliance: Xpc^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28708
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An hprt expression cassette replaced four exons and introduced a frameshift and two stop codons downstream of the mutation. RT-PCR studies of embryonic fibroblast cells detected an aberrant short Xpc transcript in homozygous mutant mice. (J:28708)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xpc Mutation: 34 strains or lines available

References

• Original: J:28708 Sands AT, et al., High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature. 1995 Sep 14;377(6545):162-5
• All: 11 reference(s)