Cdk5r1^tm1Lht
Targeted Allele Detail

Summary

• Symbol: Cdk5r1^tm1Lht
• Name: cyclin dependent kinase 5, regulatory subunit 1; targeted mutation 1, Li-Huei Tsai
• MGI ID: MGI:1931885
• Synonyms: p35-
• Gene: Cdk5r1 Location: Chr11:80367849-80372010 bp, + strand Genetic Position: Chr11, 47.94 cM
• Alliance: Cdk5r1^tm1Lht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38857
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 1.4 kb of sequence, including the entire open reading frame. (J:38857)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	125 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdk5r1 Mutation: 13 strains or lines available

References

• Original: J:38857 Chae T, et al., Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron. 1997 Jan;18(1):29-42
• All: 28 reference(s)