Numb^tm1Ynj
Targeted Allele Detail

Summary

• Symbol: Numb^tm1Ynj
• Name: NUMB endocytic adaptor protein; targeted mutation 1, Yuh Nung Jan
• MGI ID: MGI:1932085
• Synonyms: floxed-numb, fnb, m-numb(flox), numb^flox
• Gene: Numb Location: Chr12:83840808-83968708 bp, - strand Genetic Position: Chr12, 38.89 cM, cytoband D3
• Alliance: Numb^tm1Ynj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62712
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into the gene that flanked exons 5 and 6. An frt-flanked neomycin selection cassette was also inserted in an adjacent intron, but had no effect on the normal expression of the gene. (J:62712)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Numb Mutation: 59 strains or lines available

References

• Original: J:62712 Zhong W, et al., Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6844-9
• All: 14 reference(s)