Xrcc1^tm1Rpe
Targeted Allele Detail

Summary

• Symbol: Xrcc1^tm1Rpe
• Name: X-ray repair complementing defective repair in Chinese hamster cells 1; targeted mutation 1, Roger A Pedersen
• MGI ID: MGI:1932097
• Synonyms: Xrcc1-
• Gene: Xrcc1 Location: Chr7:24246124-24272863 bp, + strand Genetic Position: Chr7, 11.42 cM, cytoband A3-B2
• Alliance: Xrcc1^tm1Rpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54226
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a neomycin resistance cassette into exon 8 disrupted the Xrcc1 gene and replaced 8bp of coding sequence. Western blot analysis did not detect XRCC1 protein or truncation products in total protein extracts from cell lines made from 8.5 day embryos that were homozygous for both Xrcc1^tm1Rpe and Trp53^tm1Tyj. (J:54226)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Xrcc1 Mutation: 45 strains or lines available

References

• Original: J:54226 Tebbs RS, et al., Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev Biol. 1999 Apr 15;208(2):513-29
• All: 4 reference(s)