Nkx2-2^tm1Jlr
Targeted Allele Detail

Summary

• Symbol: Nkx2-2^tm1Jlr
• Name: NK2 homeobox 2; targeted mutation 1, John L Rubenstein
• MGI ID: MGI:1932100
• Synonyms: Nkx2.2-
• Gene: Nkx2-2 Location: Chr2:147019466-147036163 bp, - strand Genetic Position: Chr2, 72.63 cM, cytoband H
• Alliance: Nkx2-2^tm1Jlr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48576
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a PGK-neomycin resistance cassette replaced exons 1 and 2. Immunohistochemical studies of pancreas and CNS did not detect protein in homozygous mutant mice. (J:48576)

Expression

In Mice Carrying this Mutation:	37 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-2 Mutation: 14 strains or lines available

References

• Original: J:48576 Sussel L, et al., Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development. 1998 Jun;125(12):2213-21
• All: 49 reference(s)