Cenpb^tm1Rpe
Targeted Allele Detail

Summary

• Symbol: Cenpb^tm1Rpe
• Name: centromere protein B; targeted mutation 1, Roger A Pedersen
• MGI ID: MGI:1932104
• Synonyms: CENP-B null
• Gene: Cenpb Location: Chr2:131019209-131021974 bp, - strand Genetic Position: Chr2, 63.29 cM
• Alliance: Cenpb^tm1Rpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50001
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 660 bp of coding sequence. Northern and Western blot analyses of lung fibroblasts did not detect Cenpb transcript or protein in homozygous mutant mice. (J:50001)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cenpb Mutation: 18 strains or lines available

References

• Original: J:50001 Perez-Castro AV, et al., Centromeric protein B null mice are viable with no apparent abnormalities. Dev Biol. 1998 Sep 15;201(2):135-43
• All: 1 reference(s)