Arnt^tm1Oha
Targeted Allele Detail

Summary

• Symbol: Arnt^tm1Oha
• Name: aryl hydrocarbon receptor nuclear translocator; targeted mutation 1, Oliver Hankinson
• MGI ID: MGI:1932111
• Synonyms: Arnt-
• Gene: Arnt Location: Chr3:95341699-95404551 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Arnt^tm1Oha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44365
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette (pMC1neopA) was inserted into the region of the gene that encodes the basic helix-loop-helix domain of the protein. Western blot analysis using carboxy terminus antisera demonstrated that no detectable protein was present in homozygous E9.5 embryos. (J:44365)

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arnt Mutation: 65 strains or lines available

References

• Original: J:44365 Kozak KR, et al., ARNT-deficient mice and placental differentiation. Dev Biol. 1997 Nov 15;191(2):297-305
• All: 3 reference(s)