Rarg^tm2Ipc
Targeted Allele Detail

Summary

• Symbol: Rarg^tm2Ipc
• Name: retinoic acid receptor, gamma; targeted mutation 2, Pierre Chambon
• MGI ID: MGI:1932114
• Synonyms: RARgamma2-
• Gene: Rarg Location: Chr15:102143373-102165891 bp, - strand Genetic Position: Chr15, 57.4 cM, cytoband E-F3
• Alliance: Rarg^tm2Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:12691
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette into exon 5 replaced part of the 5' untranslated region of the gene for the gamma2 isoform and the A2 region sequences up to the codon for amino acid 19 (nt 81-342). This disruption is predicted to selectively prevent the synthesis of the gamma2 isoform. RNase protection analysis of E10.5 embryos indicated that the mRNA encoding the gamma2 isoform was mutated in this allele, and that the wild-type transcript for the gamma1 isoform was transcribed. (J:12691)

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rarg Mutation: 151 strains or lines available

References

• Original: J:12691 Lohnes D, et al., Function of retinoic acid receptor gamma in the mouse. Cell. 1993 May 21;73(4):643-58
• All: 4 reference(s)