F9^tm1Emg
Targeted Allele Detail

Summary

• Symbol: F9^tm1Emg
• Name: coagulation factor IX; targeted mutation 1, Erlinda M Gordon
• MGI ID: MGI:1932244
• Synonyms: F. IX
• Gene: F9 Location: ChrX:59044824-59076119 bp, + strand Genetic Position: ChrX, 33.5 cM, cytoband A6-A7
• Alliance: F9^tm1Emg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48501
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced 3.2 kb of sequence spanning exons g and h. Neither RT-PCR and Northern blot analyses detected mRNA in homozygous mutant mice. (J:48501)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F9 Mutation: 8 strains or lines available

References

• Original: J:48501 Kundu RK, et al., Targeted inactivation of the coagulation factor IX gene causes hemophilia B in mice. Blood. 1998 Jul 1;92(1):168-74
• All: 1 reference(s)