Mmp9^tm1Tvu
Targeted Allele Detail

Summary

• Symbol: Mmp9^tm1Tvu
• Name: matrix metallopeptidase 9; targeted mutation 1, Thiennu H Vu
• MGI ID: MGI:1932294
• Synonyms: Gelatinase B-Null, GelB^-, Mmp9-, MMP-9^-, MMP9^-, MMP-9 KO, MMP-9KO
• Gene: Mmp9 Location: Chr2:164782700-164797770 bp, + strand Genetic Position: Chr2, 85.27 cM, cytoband H1-H2
• Alliance: Mmp9^tm1Tvu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47297
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and all of intron 2 were replaced with a cassette containing the neomycin resistance gene driven by a PGK promoter. (J:47297)

Disease models

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mmp9^tm1Tvu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mmp9 Mutation: 50 strains or lines available

Notes

ES cell line = ZW4.

References

• Original: J:47297 Vu TH, et al., MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 1998 May 1;93(3):411-22
• All: 276 reference(s)