Foxg1^tm1(cre)Skm
Targeted Allele Detail

Summary

• Symbol: Foxg1^tm1(cre)Skm
• Name: forkhead box G1; targeted mutation 1, Susan K McConnell
• MGI ID: MGI:1932522
• Synonyms: BF1-cre, Foxg1-, Foxg1-Cre, Foxg1:Cre, Foxg1^Cre, FoxG1Cre, Foxg1^KiCre, TgH(Foxg1-Cre)1Skm
• Gene: Foxg1 Location: Chr12:49429666-49433650 bp, + strand Genetic Position: Chr12, 21.78 cM
• Alliance: Foxg1^tm1(cre)Skm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62916
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Foxg1^tm1(cre)Skm expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Foxg1 (MGI:1347464)

• Mutation details: Most of the coding region was replaced with a cre gene and a neomycin cassette. The cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. (J:62916)
• Inheritance: Recessive

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxg1 (mouse) Summary of all recombinase alleles driven by Foxg1. Comparative matrix view of recombinase activities Alliance mouse Foxg1 gene page

Disease models

Expression

In Mice Carrying this Mutation:	706 assay results 14 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Foxg1 Mutation: 29 strains or lines available

Notes

Cre mediated recombination was demonstrated in 3 reporter mouse lines in the following tissues: telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction, and pharyngeal pouches.

References

• Original: J:62916 Hebert JM, et al., Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol. 2000 Jun 15;222(2):296-306
• All: 293 reference(s)