Gpi1^b-m3Neu
Chemically and radiation induced Allele Detail

Summary

• Symbol: Gpi1^b-m3Neu
• Name: glucose-6-phosphate isomerase 1; mutant 3, Neuherberg
• MGI ID: MGI:1932543
• Gene: Gpi1 Location: Chr7:33900755-33929761 bp, - strand Genetic Position: Chr7, 19.46 cM
• Alliance: Gpi1^b-m3Neu page

Mutation origin

• Strain of Origin: (102/El x C3H/El)F1

Mutation description

• Allele Type: Chemically and radiation induced
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpi1 Mutation: 71 strains or lines available

Notes

Allele produced after treating males with both triethylenemelamine (TEM) and a single dose of gamma-irradiation. Males were crossed to wild-type females and progeny were screened for GPI activity.

Heterozygotes are viable, fertile, and phenotypically normal except that they produce only 50% of normal GPI activity. Homozygous embryos die at an early stage of development, presumably due to blockage of glycolysis (J:3054).

References

• Original: J:3054 Merkle S, et al., A glucosephosphate isomerase (GPI) null mutation in Mus musculus: evidence that anaerobic glycolysis is the predominant energy delivering pathway in early post-implantation embryos. Comp Biochem Physiol B Biochem Mol Biol. 1992 Mar;101(3):309-14
• All: 1 reference(s)