Ttpa^tm1Far
Targeted Allele Detail

Summary

• Symbol: Ttpa^tm1Far
• Name: tocopherol (alpha) transfer protein; targeted mutation 1, Bob Farese
• MGI ID: MGI:1932559
• Synonyms: alpha-TTP-KO, Ttpa-
• Gene: Ttpa Location: Chr4:20007938-20030785 bp, + strand Genetic Position: Chr4, 7.76 cM, cytoband A3
• Alliance: Ttpa^tm1Far page

Morphology of aortic lesions in Apoe^tm1Unc/Apoe^tm1Unc and Apoe^tm1Unc/Apoe^tm1Unc Ttpa^tm1Far/Ttpa^tm1Far mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66419
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin resistance cassette replaced part of the 5' untranslated region and exon 1 including the translational start codon. Immunoblot analysis of liver did not detect wild-type protein in homozygous mutant mice. (J:66419)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttpa Mutation: 23 strains or lines available

References

• Original: J:66419 Terasawa Y, et al., Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13830-4
• All: 7 reference(s)