Cr2^tm1Hmo
Targeted Allele Detail

Summary

• Symbol: Cr2^tm1Hmo
• Name: complement receptor 2; targeted mutation 1, Hector Molina
• MGI ID: MGI:1932568
• Synonyms: CD21-KO, Cr, CR1/2-, CR1/CR2-, Cr2-
• Gene: Cr2 Location: Chr1:194819119-194859024 bp, - strand Genetic Position: Chr1, 98.44 cM
• Alliance: Cr2^tm1Hmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35112
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced part of the first and all of the second exon encoding short consensus repeat (SCR) 14. Flow cytometry of spleen cells using three different rat antimouse CR2 monoclonal antibodies showed that homozygous mutant mice were deficient in the expression of the receptors. (J:35112)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cr2 Mutation: 84 strains or lines available

References

• Original: J:35112 Molina H, et al., Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3357-61
• All: 45 reference(s)