Zp2^tm1Dean
Targeted Allele Detail

Summary

• Symbol: Zp2^tm1Dean
• Name: zona pellucida glycoprotein 2; targeted mutation 1, Jurrien Dean
• MGI ID: MGI:1932591
• Synonyms: Zp2^tm, Zp2^tm1Nih, Zp2^tm2Nih
• Gene: Zp2 Location: Chr7:119725995-119744514 bp, - strand Genetic Position: Chr7, 64.38 cM
• Alliance: Zp2^tm1Dean page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67817
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and exon 2 were replaced by a neomycin cassette. Absence of the protein was confirmed by immunohistochemistry on ovarian sections of mutant female mice. (J:67817)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Zp2 Mutation: 49 strains or lines available

References

• Original: J:67817 Rankin TL, et al., Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development. 2001 Apr;128(7):1119-26
• All: 6 reference(s)