Alox12^tm1Fun
Targeted Allele Detail

Summary

• Symbol: Alox12^tm1Fun
• Name: arachidonate 12-lipoxygenase; targeted mutation 1, Colin D Funk
• MGI ID: MGI:1932927
• Synonyms: 12/15LO KO, P-12LO-
• Gene: Alox12 Location: Chr11:70132283-70146179 bp, - strand Genetic Position: Chr11, 42.99 cM
• Alliance: Alox12^tm1Fun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46896
• Parent Cell Line: D3H (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 8. Western blot analysis did not detect the encoded protein in homozygous mutant platelets. (J:46896)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Alox12 Mutation: 39 strains or lines available

References

• Original: J:46896 Johnson EN, et al., Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3100-5
• All: 27 reference(s)