Map4k4^tm1Eys
Targeted Allele Detail

Summary

• Symbol: Map4k4^tm1Eys
• Name: mitogen-activated protein kinase kinase kinase kinase 4; targeted mutation 1, Edward Y Skolnik
• MGI ID: MGI:1933044
• Synonyms: Nik-
• Gene: Map4k4 Location: Chr1:39940073-40065470 bp, + strand Genetic Position: Chr1, 18.53 cM, cytoband B
• Alliance: Map4k4^tm1Eys page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68215
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of half of exon 6 and all of exon 7, encoding part of the kinase domain, with a neomycin cassette. mRNA was undetectable in Northern blots in homozygous ES cells and in fibroblasts derived from homozyogous mutant mice. (J:68215)

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map4k4 Mutation: 105 strains or lines available

References

• Original: J:68215 Xue Y, et al., Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development. 2001 May;128(9):1559-72
• All: 2 reference(s)