Tgfa^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Tgfa^tm1Unc
• Name: transforming growth factor alpha; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1933208
• Synonyms: TGFalpha^-, Tgfa^tm1Dcl
• Gene: Tgfa Location: Chr6:86172205-86252701 bp, + strand Genetic Position: Chr6, 37.62 cM
• Alliance: Tgfa^tm1Unc page

Phenotypes of Egfr^wa2/Egfr^Wa5 and Tgfa^tm1Unc/Tgfa^tm1Unc Egfr^Wa5/⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4605
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 4. Homozygous mutant mice do not express mRNA from this allele. Protein was undetectable in homozygous mutant macrophages in a radioimmunoassay. (J:4605)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tgfa Mutation: 17 strains or lines available

References

• Original: J:4605 Luetteke NC, et al., TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell. 1993 Apr 23;73(2):263-78
• All: 15 reference(s)