Rora^tm1Vgi
Targeted Allele Detail

Summary

• Symbol: Rora^tm1Vgi
• Name: RAR-related orphan receptor alpha; targeted mutation 1, Vincent Giguere
• MGI ID: MGI:1933211
• Synonyms: Rora^-
• Gene: Rora Location: Chr9:68561068-69295528 bp, + strand Genetic Position: Chr9, 37.45 cM
• Alliance: Rora^tm1Vgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46140
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Insertion of a neomycin cassette into exon 3. An mRNA is expressed from this allele, although at lower levels than wild-type. No protein was detectable by immunohistochemistry in Purkinje cells in the cerebellum of 21 day old mice. (J:46140)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rora Mutation: 43 strains or lines available

References

• Original: J:46140 Dussault I, et al., Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer. Mech Dev. 1998 Jan;70(1-2):147-53
• All: 3 reference(s)