Msgn1^tm1Wb
Targeted Allele Detail

Summary

• Symbol: Msgn1^tm1Wb
• Name: mesogenin 1; targeted mutation 1, Barbara Wold
• MGI ID: MGI:1933263
• Synonyms: pMesogenin1-, pMesogenin1^lacZ,neo
• Gene: Msgn1 Location: Chr12:11258383-11258949 bp, - strand Genetic Position: Chr12, 5.58 cM, cytoband A2
• Alliance: Msgn1^tm1Wb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66514
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In-frame insertion of a LacZ and PGK-neomycin resistance cassette at the presumptive initiation codon with replacement of the entire protein coding sequence of the gene. Two loxP sites flanked the PGK-neo sequences. (J:66514)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msgn1 Mutation: 6 strains or lines available

References

• Original: J:66514 Yoon JK, et al., The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev. 2000 Dec 15;14(24):3204-14
• All: 3 reference(s)