Shc3^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Shc3^tm1Paw
• Name: src homology 2 domain-containing transforming protein C3; targeted mutation 1, Tony Pawson
• MGI ID: MGI:1933356
• Synonyms: Rai^-, ShcC-
• Gene: Shc3 Location: Chr13:51585077-51723523 bp, - strand Genetic Position: Chr13, 26.12 cM
• Alliance: Shc3^tm1Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66508
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an IRES-LacZ cassette disrupted the Shc3 gene. SHC3 antibodies did not detect protein in 4 week old homozygous mutant brain. (J:66508)

Expression

In Mice Carrying this Mutation:

32 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shc3 Mutation: 35 strains or lines available

References

• Original: J:66508 Sakai R, et al., The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 2000 Dec;28(3):819-33
• All: 10 reference(s)