Cr2^tm1Crr
Targeted Allele Detail

Summary

• Symbol: Cr2^tm1Crr
• Name: complement receptor 2; targeted mutation 1, Michael C Carroll
• MGI ID: MGI:1933715
• Synonyms: Cr2-, Cr2^def
• Gene: Cr2 Location: Chr1:194819119-194859024 bp, - strand Genetic Position: Chr1, 98.44 cM
• Alliance: Cr2^tm1Crr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31942
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin resistance cassette into short consensus repeat (SCR) 10 disrupted the gene by introducing a frameshift mutation and a stop codon. Immunohistochemical staining and flow cytometric analysis detected negligible expression in splenic B cells of homozygous mutant mice. (J:31942)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cr2 Mutation: 84 strains or lines available

References

• Original: J:31942 Ahearn JM, et al., Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity. 1996 Mar;4(3):251-62
• All: 31 reference(s)