Lfng^tm1Rjo
Targeted Allele Detail

Summary

• Symbol: Lfng^tm1Rjo
• Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Randy L Johnson
• MGI ID: MGI:1933737
• Synonyms: Lfng-
• Gene: Lfng Location: Chr5:140593096-140601300 bp, + strand Genetic Position: Chr5, 79.15 cM
• Alliance: Lfng^tm1Rjo page

Irregular sacral segmentation in Hes7^tm1Kag/Hes7^tm1Kag mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48859
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 of the Lnfg gene, including the translational start site, the signal sequence, and a putative processing site. The authors predict the mutant allele would be a null mutation, and report that Lnfg mRNA is not detected in homozygous mutant embryos. (J:48859)

Expression

In Mice Carrying this Mutation:	91 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lfng Mutation: 32 strains or lines available

References

• Original: J:48859 Evrard YA, et al., lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 1998 Jul 23;394(6691):377-81
• All: 25 reference(s)