Atm^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Atm^tm1Pmc
• Name: ataxia telangiectasia mutated; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:1933746
• Synonyms: Atm-
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin gene interrupts exon 57 and replaces exon 58. This region corresponds to a region deleted in some human AT deficiency cases. (J:47752)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 170 strains or lines available

References

• Original: J:47752 Herzog KH, et al., Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science. 1998 May 15;280(5366):1089-91
• All: 38 reference(s)