Cdkn1a^tm1Tyj
Targeted Allele Detail

Summary

• Symbol: Cdkn1a^tm1Tyj
• Name: cyclin dependent kinase inhibitor 1A; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:1933751
• Synonyms: Cdkn1a-, p21-, p21^cip-
• Gene: Cdkn1a Location: Chr17:29309953-29319696 bp, + strand Genetic Position: Chr17, 15.12 cM
• Alliance: Cdkn1a^tm1Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68068
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequences were replaced by a neomycin cassette. No protein was detected by immunoprecipitation of ES cell lysates in which both alleles were disrupted. (J:68068)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	19 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn1a^tm1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1a Mutation: 63 strains or lines available

References

• Original: J:68068 Brugarolas J, et al., Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature. 1995 Oct 12;377(6549):552-7
• All: 193 reference(s)