Cdkn1c^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Cdkn1c^tm1Bbd
• Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1933757
• Synonyms: p57^kip2 (-)
• Gene: Cdkn1c Location: Chr7:143012076-143014735 bp, - strand Genetic Position: Chr7, 88.22 cM
• Alliance: Cdkn1c^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40142
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Deletion of 1.1 kb of genomic sequence that includes the first exon and half the second exon, encoding amino acid residues 1-181 of the protein. No protein was detected in Western blots of lysates of primary embryo fibroblasts derived from homozygous mutant mice. (J:40142)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1c Mutation: 19 strains or lines available

References

• Original: J:40142 Yan Y, et al., Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes Dev. 1997 Apr 15;11(8):973-83
• All: 5 reference(s)