Cdkn1c^tm1Kat
Targeted Allele Detail

Summary

• Symbol: Cdkn1c^tm1Kat
• Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1, Katsuhiko Takahashi
• MGI ID: MGI:1933758
• Synonyms: p57-, p57^Kip2(-)
• Gene: Cdkn1c Location: Chr7:143012076-143014735 bp, - strand Genetic Position: Chr7, 88.22 cM
• Alliance: Cdkn1c^tm1Kat page

Representative testes, seminal vesicles, and uteri from wild-type, Cdkn1c^tm1Kat/Cdkn1c⁺, and Cdkn1c^{tm1.1(Cdkn1b*)Kei}/Cdkn1c⁺ mice at 7 weeks of age

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61190
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the entire coding region, including exons 1, 2, 3 and part of exon 4 with a neomycin cassette. (J:61190)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	12 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	25 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1c Mutation: 19 strains or lines available

References

• Original: J:61190 Takahashi K, et al., Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation. J Biochem. 2000 Jan;127(1):73-83
• All: 13 reference(s)