Cdkn2b^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Cdkn2b^tm1Bbd
• Name: cyclin dependent kinase inhibitor 2B; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1933760
• Synonyms: p15^INK4b-
• Gene: Cdkn2b Location: Chr4:89224536-89229276 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2b^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63299
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, encoding amino acids 44-130, was replaced by a neomycin cassette. No protein was detectable in Western blots of immunoprecipitates of MEF lysates derived from homozygous mutant embryos. (J:63299)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2b^tm1Bbd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn2b Mutation: 7 strains or lines available

References

• Original: J:63299 Latres E, et al., Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 2000 Jul 3;19(13):3496-506
• All: 10 reference(s)