Msx1^tm1Bero
Targeted Allele Detail

Summary

• Symbol: Msx1^tm1Bero
• Name: msh homeobox 1; targeted mutation 1, Benoit Robert
• MGI ID: MGI:1933766
• Synonyms: Msx1-, Msx1-nlacZ, Msx1^nlacZ
• Gene: Msx1 Location: Chr5:37977835-37981929 bp, - strand Genetic Position: Chr5, 20.21 cM
• Alliance: Msx1^tm1Bero page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42035
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An n-lacZ reporter gene was inserted in-frame into the sequence encoding the third helix of the homeodomain. A fusion protein of the first 43 amino acids and beta-galactosidase is expressed from this allele. (J:42035)

Disease models

Expression

In Mice Carrying this Mutation:	282 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msx1 Mutation: 18 strains or lines available

References

• Original: J:42035 Houzelstein D, et al., Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene. Mech Dev. 1997 Jul;65(1-2):123-33
• All: 28 reference(s)