Myf5^tm2(Myog)Jae
Targeted Allele Detail

Summary

• Symbol: Myf5^tm2(Myog)Jae
• Name: myogenic factor 5; targeted mutation 2, Rudolf Jaenisch
• MGI ID: MGI:1933774
• Synonyms: Myf5^myg, Myf5^myg-ki
• Gene: Myf5 Location: Chr10:107318769-107321995 bp, - strand Genetic Position: Chr10, 55.95 cM
• Alliance: Myf5^tm2(Myog)Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31611
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of all Myf5 coding sequences in exon 1 and replacement with the complete Myog coding region followed by a stop codon. A lox-P flanked neomycin cassette was also inserted downstream of the Myog coding region, but was removed via Cre-mediated recombination in ES cells prior to the generation of chimeric founder mice. This allele expresses a functional Myogenin protein under the control of the Myf5 promoter. (J:31611)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf5 Mutation: 17 strains or lines available

References

• Original: J:31611 Wang Y, et al., Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin. Nature. 1996 Feb 29;379(6568):823-5
• All: 3 reference(s)