Ntf3^tm1Par
Targeted Allele Detail

Summary

• Symbol: Ntf3^tm1Par
• Name: neurotrophin 3; targeted mutation 1, Luis F Parada
• MGI ID: MGI:1933844
• Synonyms: NT-3-, NT-3^BRP, NT-3^neo
• Gene: Ntf3 Location: Chr6:126078375-126143703 bp, - strand Genetic Position: Chr6, 60.45 cM
• Alliance: Ntf3^tm1Par page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67562
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin cassette was inserted into the only coding exon, disrupting gene function. (J:67562, J:97779)

Disease models

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	42 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntf3 Mutation: 24 strains or lines available

References

• Original: J:67562 Tessarollo L, et al., Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11844-8
• All: 16 reference(s)