Ntrk1^tm1Par
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1Par
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Luis F Parada
• MGI ID: MGI:1933963
• Synonyms: TrkA-
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1Par page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60927
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced all coding sequences except the first 53 nucleotides of the exon that contains the translation initiation codon. (J:60927)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 62 strains or lines available

References

• Original: J:60927 Liebl DJ, et al., Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302
• All: 9 reference(s)