Ntrk2^tm2Kln
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm2Kln
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 2, Rudiger Klein
• MGI ID: MGI:1933974
• Synonyms: trkB^lox, Trkb^lx
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm2Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58229
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Insertion of loxP sites flanking exon K2, encoding sequences in the kinase domain of the protein. An adjacent frt-flanked neomycin cassette was removed by crossing to transgenic mice expressing the Flp recombinase. This mutation had no effect on the normal function of the gene. (J:58229)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:58229 Minichiello L, et al., Essential role for TrkB receptors in hippocampus-mediated learning. Neuron. 1999 Oct;24(2):401-14
• All: 19 reference(s)