Cd14^tm1Frm
Targeted Allele Detail

Summary

• Symbol: Cd14^tm1Frm
• Name: CD14 antigen; targeted mutation 1, Mason W Freeman
• MGI ID: MGI:1934009
• Synonyms: CD14-
• Gene: Cd14 Location: Chr18:36858120-36859851 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Cd14^tm1Frm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65107
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing the entire coding sequences of the gene. Western blot analysis confirmed an absence of CD14 protein in macrophage lysates derived from homozygous mice. (J:65107)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cd14 Mutation: 22 strains or lines available

References

• Original: J:65107 Moore KJ, et al., Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15;165(8):4272-80
• All: 106 reference(s)