Dgat1^tm1Far
Targeted Allele Detail

Summary

• Symbol: Dgat1^tm1Far
• Name: diacylglycerol O-acyltransferase 1; targeted mutation 1, Bob Farese
• MGI ID: MGI:1934012
• Gene: Dgat1 Location: Chr15:76386215-76396153 bp, - strand Genetic Position: Chr15, 35.99 cM
• Alliance: Dgat1^tm1Far page

Enhanced epidermal response to topical retinol treatment in Dgat1^tm1Far/Dgat1^tm1Far mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61885
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing sequences encoding the carboxy-terminus of the protein was replaced by a neomycin cassette. Northern blot analysis did not detect a full length transcript produced from this allele in homozygous mice. Tissue DGAT activity was absent ot severely reduced in homozygous mice. (J:61885)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dgat1 Mutation: 33 strains or lines available

References

• Original: J:61885 Smith SJ, et al., Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat [see comments]. Nat Genet. 2000 May;25(1):87-90
• All: 33 reference(s)