Il15ra^tm1Ama
Targeted Allele Detail

Summary

• Symbol: Il15ra^tm1Ama
• Name: interleukin 15 receptor, alpha chain; targeted mutation 1, Averil Ma
• MGI ID: MGI:1934016
• Synonyms: Il-15R^-, Il15ra-, IL-15Ralpha-, IL-15Ralpha^-, RalphaKO
• Gene: Il15ra Location: Chr2:11710101-11739128 bp, + strand Genetic Position: Chr2, 8.97 cM
• Alliance: Il15ra^tm1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51337
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 2 and 3 was replaced by a neomycin resistance cassette. These sequences encode the ligand binding and proline/threonine rich extracellular domains. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. (J:51337)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il15ra Mutation: 39 strains or lines available

References

• Original: J:51337 Lodolce JP, et al., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998 Nov;9(5):669-76
• All: 80 reference(s)