Il15ra^tm1Ama
Targeted Allele Detail

Summary

• Symbol: Il15ra^tm1Ama
• Name: interleukin 15 receptor, alpha chain; targeted mutation 1, Averil Ma
• MGI ID: MGI:1934016
• Synonyms: Il-15R^-, Il15ra-, IL-15Ralpha-, IL-15Ralpha^-, RalphaKO
• Gene: Il15ra Location: Chr2:11710101-11739128 bp, + strand Genetic Position: Chr2, 8.97 cM
• Alliance: Il15ra^tm1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51337
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 2 and 3 was replaced by a neomycin resistance cassette. These sequences encode the ligand binding and proline/threonine rich extracellular domains. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. (J:51337)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Il15ra^tm1Ama/Il15ra^tm1Ama	involves: 129X1/SvJ
cn2	Il15ra^tm1Ama/Il15ra^tm2.1Ama Lyz2^tm1(cre)Ifo/0 Tg(Itgax-cre)1-1Reiz/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
cn3	Il15ra^tm1Ama/Il15ra^tm2.1Ama Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
cn4	Il15ra^tm1Ama/Il15ra^tm2.1Ama Tg(Itgax-cre)1-1Reiz/0	involves: 129X1/SvJ * C57BL/6J * CBA
cn5	Il15ra^tm1Ama/Il15ra^tm2.1Ama Tg(Vil1-cre)997Gum/0	involves: C57BL/6J * SJL

Phenotypes:

Affected Systems	hm1	cn2	cn3	cn4	cn5
show or hide all annotated terms
cellular	√
decreased T cell proliferation	√
hematopoietic system	√	√	√	√	√
decreased T cell proliferation	√
abnormal NK cell differentiation			√	√
decreased NK cell number	√	√	√	√
abnormal T cell subpopulation ratio				√
decreased CD8-positive, alpha-beta T cell number	√	√	√	√
decreased NK T cell number	√
decreased CD8-positive, gamma-delta intraepithelial T cell number	√				√
decreased memory T cell number	√	√	√	√
abnormal NK cell physiology	√		√	√
impaired natural killer cell mediated cytotoxicity	√
immune system	√	√	√	√	√
abnormal NK cell differentiation			√	√
decreased NK cell number	√	√	√	√
abnormal T cell subpopulation ratio				√
decreased CD8-positive, alpha-beta T cell number	√	√	√	√
decreased NK T cell number	√
decreased CD8-positive, gamma-delta intraepithelial T cell number	√				√
decreased memory T cell number	√	√	√	√
abnormal immune system physiology		√	√
decreased T cell proliferation	√
abnormal NK cell physiology	√		√	√
impaired natural killer cell mediated cytotoxicity	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il15ra Mutation: 39 strains or lines available

References

• Original: J:51337 Lodolce JP, et al., IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998 Nov;9(5):669-76
• All: 80 reference(s)