Il1rap^tm1Roml
Targeted Allele Detail

Summary

• Symbol: Il1rap^tm1Roml
• Name: interleukin 1 receptor accessory protein; targeted mutation 1, Mark A Labow
• MGI ID: MGI:1934017
• Synonyms: IL-1RAcP-, IL1 receptor AcP KO
• Gene: Il1rap Location: Chr16:26400454-26548867 bp, + strand Genetic Position: Chr16, 18.21 cM, cytoband B2
• Alliance: Il1rap^tm1Roml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68065
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons D1 and part of D2A. These exons encode the first Ig domain and part of the second Ig domain. Northern blot analysis revealed that a truncated mRNA was produced from this allele, but equilibrium binding studies demonstrated that no protein was present on the cell surface of primary mouse embryo fibroblasts (PMEFs) derived from homozygous mice. (J:68065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1rap Mutation: 54 strains or lines available

References

• Original: J:68065 Cullinan EB, et al., IL-1 receptor accessory protein is an essential component of the IL-1 receptor. J Immunol. 1998 Nov 15;161(10):5614-20
• All: 20 reference(s)