P2rx3^tm1Ckn
Targeted Allele Detail

Summary

• Symbol: P2rx3^tm1Ckn
• Name: purinergic receptor P2X, ligand-gated ion channel, 3; targeted mutation 1, Debra A Cockayne
• MGI ID: MGI:1934019
• Synonyms: P2X3-
• Gene: P2rx3 Location: Chr2:84828927-84867806 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: P2rx3^tm1Ckn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65557
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance gene via homologous recombination, thus deleting the translation initiation codon. Protein product was absent from dorsal root ganglion, spinal cord, and peripheral tissues of homozygous mutant animals as shown by immunohistochemistry. (J:65557)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any P2rx3 Mutation: 21 strains or lines available

References

• Original: J:65557 Cockayne DA, et al., Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature. 2000 Oct 26;407(6807):1011-5
• All: 22 reference(s)