Per2^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Per2^tm1Brd
• Name: period circadian clock 2; targeted mutation 1, Allan Bradley
• MGI ID: MGI:1934020
• Synonyms: mPer2^Brdm1, mPer2^m, Per2^Brdm1
• Gene: Per2 Location: Chr1:91343699-91387028 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56167
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons containing the most conserved region of the gene were replaced with PGK-neo cassette, resulting in the deletion of the PAC subdomain and half of the PAS B domain. RT-PCR and sequence analysis of mutant animals detected a mutant transcript with a predicted protein containing an 87 amino acid deletion. (J:56167)

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Per2^tm1Brd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 73 strains or lines available

References

• Original: J:56167 Zheng B, et al., The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature. 1999 Jul 8;400(6740):169-73
• All: 100 reference(s)