Trpv1^tm1Jul
Targeted Allele Detail

Summary

• Symbol: Trpv1^tm1Jul
• Name: transient receptor potential cation channel, subfamily V, member 1; targeted mutation 1, David Julius
• MGI ID: MGI:1934023
• Synonyms: Trpv-1^-, TRPV1-KO, Vr1^tm1Jul
• Gene: Trpv1 Location: Chr11:73125118-73152068 bp, + strand Genetic Position: Chr11, 45.25 cM, cytoband B3
• Alliance: Trpv1^tm1Jul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61534
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by deleting an exon encoding part of the fifth and all of the sixth putative transmembrane domains of the channel, together with the intervening pore-loop region. Northern blot analysis showed that mRNA derived from dorsal root ganglia (DRG) of homozygous mice lacked detectable transcripts encoded by this allele. (J:61534)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpv1 Mutation: 60 strains or lines available

References

• Original: J:61534 Caterina MJ, et al., Impaired nociception and pain sensation in mice lacking the capsaicin receptor [see comments]. Science. 2000 Apr 14;288(5464):306-13
• All: 361 reference(s)